BDBM50048953 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid::4'-(2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid 4(FTI-265)::CHEMBL417600

SMILES N[C@@H](CS)CNc1ccc(cc1)-c1cccc(c1)C(O)=O

InChI Key InChIKey=GVHAKJDMTSSDKK-CQSZACIVSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50048953   

TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50048953(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  150nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048953(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048953(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  1.00E+5nMAssay Description:Activity against Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048953(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  1.00E+5nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048953(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  50nMAssay Description:Activity against rat brain FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048953(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  114nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed