BDBM50051317 (3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine::CHEMBL306081

SMILES Cc1[nH]c2ncnc(Nc3cccc(Cl)c3)c2c1C

InChI Key InChIKey=WXJDWBDGDSXEFA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50051317   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051317((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  300nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051317((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051317((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  27nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051317((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  4.05E+4nMAssay Description:Inhibition of tyrosine kinase v-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051317((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  27nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051317((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of tyrosine kinase c-SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed