BDBM50051565 4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide::4-[4-(2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide::CHEMBL69759::Sonepiprazole

SMILES NS(=O)(=O)c1ccc(cc1)N1CCN(CC[C@@H]2OCCc3ccccc23)CC1

InChI Key InChIKey=WNUQCGWXPNGORO-UHFFFAOYSA-N

Data  24 KI

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50051565   

TargetCarbonic anhydrase 7(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of recombinant human CA7 extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Rat)
Pharmacia & Upjohn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  7.20nMAssay Description:Binding affinity of [3H]spiperone towards Dopamine receptor D4 expressed in cultured cells or from rat whole brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 6(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant human CA6 extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCarbonic anhydrase 13(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  18nMAssay Description:Inhibition of recombinant human CA13 extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  29nMAssay Description:Inhibition of recombinant human CA9 extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  31nMAssay Description:Inhibition of recombinant human CA2 extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  42nMAssay Description:Inhibition of recombinant human CA12 extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCarbonic anhydrase 14(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  44nMAssay Description:Inhibition of recombinant human CA14 extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCarbonic anhydrase 5B, mitochondrial(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  47nMAssay Description:Inhibition of recombinant human CA5B extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  60nMAssay Description:Inhibition of recombinant human CA5A extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  90nMAssay Description:Inhibition of recombinant human CA1 extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi: >1.60E+3nMAssay Description:Inhibition of alpha2A adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi: >1.60E+3nMAssay Description:Inhibition of serotonin 5-HT2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi: >1.60E+3nMAssay Description:Inhibition of histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi: >1.60E+3nMAssay Description:Inhibition of serotonin 5-HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi: >2.78E+3nMAssay Description:Inhibition of human dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Pharmacia & Upjohn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi: >3.70E+3nMAssay Description:Binding affinity of [3H]-8-OH-DPAT towards 5-hydroxytryptamine 1A receptor in cloned mammalian receptor expressed in cultured cells or from rat whole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Pharmacia & Upjohn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi: >4.30E+3nMAssay Description:Binding affinity of [3H]U-86170 towards Dopamine receptor D2 in cloned mammalian receptor expressed in cultured cells or from rat whole brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  5.15E+3nMAssay Description:Inhibition of human dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Pharmacia & Upjohn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  5.80E+3nMAssay Description:Binding affinity of [3H]spiperone towards Dopamine receptor D3 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi:  7.68E+3nMAssay Description:Inhibition of recombinant human CA4 extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetD(1A) dopamine receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi: >8.38E+3nMAssay Description:Inhibition of human dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 3(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051565BDBM50051565(4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human CA3 extracted from Escherichia coli BL21 (DE3) cells incubated for 15 mins by phenol red dye based stopped flow CO2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed