BDBM50051931 CHEMBL32635::N*6*-Naphthalen-1-ylmethyl-pyrido[2,3-d]pyrimidine-2,4,6-triamine

SMILES Nc1nc(N)c2cc(NCc3cccc4ccccc34)cnc2n1

InChI Key InChIKey=LBPDIYOTQUYXDA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50051931   

TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051931(N*6*-Naphthalen-1-ylmethyl-pyrido[2,3-d]pyrimidine...)
Affinity DataIC50: 240nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051931(N*6*-Naphthalen-1-ylmethyl-pyrido[2,3-d]pyrimidine...)
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051931(N*6*-Naphthalen-1-ylmethyl-pyrido[2,3-d]pyrimidine...)
Affinity DataIC50: 980nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051931(N*6*-Naphthalen-1-ylmethyl-pyrido[2,3-d]pyrimidine...)
Affinity DataIC50: 980nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051931(N*6*-Naphthalen-1-ylmethyl-pyrido[2,3-d]pyrimidine...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051931(N*6*-Naphthalen-1-ylmethyl-pyrido[2,3-d]pyrimidine...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed