BDBM50052039 18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::CHEMBL292495::LY-326449

SMILES OC[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21

InChI Key InChIKey=BGVKOUSMQGMSDY-INIZCTEOSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50052039   

TargetProtein kinase C alpha type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50:  720nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Protein kinase C etaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50:  28nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50:  73nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50:  550nMAssay Description:Inhibition of rat brain PKCMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50:  7.90E+4nMAssay Description:Inhibition of Protein kinase C epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C zeta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of Protein kinase C zetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C gamma type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50:  32nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C delta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052039(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Affinity DataIC50:  690nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed