BDBM50054512 2-Amino-5-(4-chloro-phenylsulfanyl)-6-methyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one::CHEMBL142176

SMILES Cc1[nH]c2nc(N)[nH]c(=O)c2c1Sc1ccc(Cl)cc1

InChI Key InChIKey=KXJWEXFVYFDHEI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50054512   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50054512(2-Amino-5-(4-chloro-phenylsulfanyl)-6-methyl-3,7-d...)
Affinity DataIC50:  3.10E+3nMAssay Description:The inhibitory concentration of compound against Dihydrofolate reductases on Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50054512(2-Amino-5-(4-chloro-phenylsulfanyl)-6-methyl-3,7-d...)
Affinity DataIC50:  5.30E+3nMAssay Description:The inhibitory concentration of compound was evaluated on Pneumocystis carini Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50054512(2-Amino-5-(4-chloro-phenylsulfanyl)-6-methyl-3,7-d...)
Affinity DataIC50: >2.60E+4nMAssay Description:The inhibitory concentration of compound was evaluated on Escherichia coli Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50054512(2-Amino-5-(4-chloro-phenylsulfanyl)-6-methyl-3,7-d...)
Affinity DataIC50:  1.00E+3nMAssay Description:The inhibitory concentration of compound was evaluated on Human Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50054512(2-Amino-5-(4-chloro-phenylsulfanyl)-6-methyl-3,7-d...)
Affinity DataIC50: >2.60E+3nMAssay Description:The inhibitory concentration of compound was evaluated on Lactobacillus casei Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50054512(2-Amino-5-(4-chloro-phenylsulfanyl)-6-methyl-3,7-d...)
Affinity DataIC50:  4.00E+4nMAssay Description:The inhibitory concentration of compound against Dihydrofolate reductases on Pneumocystis carini (pc)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50054512(2-Amino-5-(4-chloro-phenylsulfanyl)-6-methyl-3,7-d...)
Affinity DataIC50:  2.46E+4nMAssay Description:The inhibitory concentration of compound against Dihydrofolate reductases on rat liver (rl)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50054512(2-Amino-5-(4-chloro-phenylsulfanyl)-6-methyl-3,7-d...)
Affinity DataIC50:  3.00E+4nMAssay Description:The inhibitory concentration of compound was evaluated on Streptococcus faecium Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed