BDBM50054601 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide::5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide::5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide::Arava (TN)::CHEMBL960::LEFLUNOMIDE::alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide

SMILES Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N

Data  14 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50054601   

TargetMatrix metalloproteinase-14 [1-36](Homo sapiens (Human))
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataEC50:  5.65E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  1.77E+5nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  1.12E+5nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of DHODH in Wistar rat liver homogenates by DCIP reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration tested against enzyme dihydroorotate dehydrogenase in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  1.30E+4nMAssay Description:In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProtein-arginine deiminase type-4(Homo sapiens (Human))
University Of South Carolina

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  2.40E+6nMAssay Description:Inhibition of PAD4 by ABPP-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  1.00E+4nMAssay Description:Immunosuppressive activity of the compound expressed as ability to inhibit human recombinant dihydroorotate dehydrogenase (DHODH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank