BDBM50056358 CHEMBL3326581

SMILES Cc1cc2c(NC(=O)N[C@@H]3CC(C)(C)Oc4cc(F)ccc34)cccc2cn1

InChI Key InChIKey=QGYOUMYRQKOXET-LJQANCHMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50056358   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50056358(CHEMBL3326581)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50056358(CHEMBL3326581)
Affinity DataIC50:  3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50056358(CHEMBL3326581)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed