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BDBM50057248 CHEMBL3326131

SMILES: COc1cccc(Sc2ccc3nnc(-c4ccccc4)n3n2)c1

InChI Key: InChIKey=NQRIOISUZBMCTP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50057248   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50057248
PNG
(CHEMBL3326131)
Show SMILES COc1cccc(Sc2ccc3nnc(-c4ccccc4)n3n2)c1
Show InChI InChI=1S/C18H14N4OS/c1-23-14-8-5-9-15(12-14)24-17-11-10-16-19-20-18(22(16)21-17)13-6-3-2-4-7-13/h2-12H,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.11E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged truncated LRRK2 (unknown origin) using fluorescein-labeled peptide LRRKtide as substrate by LANTHA screen assay in presence ...


Bioorg Med Chem Lett 24: 4132-40 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.052
BindingDB Entry DOI: 10.7270/Q2D50PMD
More data for this
Ligand-Target Pair