BDBM50057538 4-[5-(4-Hydroxymethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide::4-[5-(4-Hydroxymethylphenyl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonamide::CHEMBL745::Primary alcohol metabolite of celecoxib

SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(CO)cc1)C(F)(F)F

InChI Key InChIKey=ICRSYPPLGADZKA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50057538   

TargetProstaglandin G/H synthase 2(Sheep)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50057538(4-[5-(4-Hydroxymethyl-phenyl)-3-trifluoromethyl-py...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50057538(4-[5-(4-Hydroxymethyl-phenyl)-3-trifluoromethyl-py...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057538(4-[5-(4-Hydroxymethyl-phenyl)-3-trifluoromethyl-py...)
Affinity DataIC50: 9.33E+4nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057538(4-[5-(4-Hydroxymethyl-phenyl)-3-trifluoromethyl-py...)
Affinity DataIC50: 9.33E+4nMAssay Description:Inhibitory concentration against human prostaglandin G/H synthase 2 at 25 degrees.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50057538(4-[5-(4-Hydroxymethyl-phenyl)-3-trifluoromethyl-py...)
Affinity DataIC50: 9.33E+4nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50057538(4-[5-(4-Hydroxymethyl-phenyl)-3-trifluoromethyl-py...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057538(4-[5-(4-Hydroxymethyl-phenyl)-3-trifluoromethyl-py...)
Affinity DataIC50: 1.00E+6nMAssay Description:In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed