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BDBM50058989 3-(4-Nitro-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dione::CHEMBL69009

SMILES: [O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1

InChI Key: InChIKey=XYVDRLPWUBVVHJ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50058989   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chymase


(Homo sapiens (human))
BDBM50058989
PNG
(3-(4-Nitro-benzenesulfonyl)-1-phenyl-imidazolidine...)
Show SMILES [O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1
Show InChI InChI=1S/C15H11N3O6S/c19-14-10-16(11-4-2-1-3-5-11)15(20)17(14)25(23,24)13-8-6-12(7-9-13)18(21)22/h1-9H,10H2
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 700n/an/an/an/an/an/a



Suntory Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against human heart chymase in vitro.


J Med Chem 40: 2156-63 (1997)


Article DOI: 10.1021/jm960793t
BindingDB Entry DOI: 10.7270/Q2QJ7GDG
More data for this
Ligand-Target Pair
Alpha-chymotrypsin


(Bos taurus (bovine))
BDBM50058989
PNG
(3-(4-Nitro-benzenesulfonyl)-1-phenyl-imidazolidine...)
Show SMILES [O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1
Show InChI InChI=1S/C15H11N3O6S/c19-14-10-16(11-4-2-1-3-5-11)15(20)17(14)25(23,24)13-8-6-12(7-9-13)18(21)22/h1-9H,10H2
PDB
MMDB

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KEGG

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Suntory Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against bovine pancreas alpha-chymotrypsin in vitro


J Med Chem 40: 2156-63 (1997)


Article DOI: 10.1021/jm960793t
BindingDB Entry DOI: 10.7270/Q2QJ7GDG
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50058989
PNG
(3-(4-Nitro-benzenesulfonyl)-1-phenyl-imidazolidine...)
Show SMILES [O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1
Show InChI InChI=1S/C15H11N3O6S/c19-14-10-16(11-4-2-1-3-5-11)15(20)17(14)25(23,24)13-8-6-12(7-9-13)18(21)22/h1-9H,10H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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DrugBank
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.50E+3n/an/an/an/an/an/a



Suntory Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against human neutrophil cathepsin G.


J Med Chem 40: 2156-63 (1997)


Article DOI: 10.1021/jm960793t
BindingDB Entry DOI: 10.7270/Q2QJ7GDG
More data for this
Ligand-Target Pair