BDBM50059033 (11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid ethyl ester::(3S,16S)-apovincaminic acid ethylester::(3aS,11bS)-3a-ethyl-1,2,3,3a,10,11b-hexahydro-11H-5a,11a-diaza-benzo[cd]fluoranthene-5-carboxylic acid ethyl ester::11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid 2-nitrooxy-ethyl ester(Vinpocetine)::CHEMBL71752::Vinpocetine::cid_443955

SMILES CC[C@@]12CCCN3[C@@H]1c4c(c5ccccc5n4C(=C2)C(=O)OCC)CC3

InChI Key InChIKey=DDNCQMVWWZOMLN-UHFFFAOYSA-N

Data  1 KI  11 IC50  1 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50059033   

LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataKd:  14nMAssay Description:Binding affinity to PDE1A (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 7.99E+3nMAssay Description:Inhibition of human recombinant PDE1B using cAMP as substrate incubated for 20 mins measured by Kinase Glo reagent based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human phosphodiesterase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of PDE1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGenome polyprotein(WNV)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 5.00E+4nMAssay Description:The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH0776...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetHeat shock factor protein 1(Mouse)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataEC50: >1.95E+5nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2011
Entry Details
PCBioAssay
TargetPhosphodiesterase(Bovine)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibitory activity against phosphodiesterase 3 (PDE3) purified from bovine heartMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 3.00E+5nMAssay Description:Evaluated for inhibitory activity against Phosphodiesterase 5 (PDE5) purified from bovine lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed