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BDBM50059097 5-Methyl-2-p-tolyl-1H-[1,8]naphthyridin-4-one::CHEMBL49267

SMILES: Cc1ccc(cc1)-c1cc(O)c2c(C)ccnc2n1

InChI Key: InChIKey=YMGBUMKFZOUPGE-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50059097   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tubulin


(Sus scrofa (Pig))
BDBM50059097
PNG
(5-Methyl-2-p-tolyl-1H-[1,8]naphthyridin-4-one | CH...)
Show SMILES Cc1ccc(cc1)-c1cc(O)c2c(C)ccnc2n1
Show InChI InChI=1S/C16H14N2O/c1-10-3-5-12(6-4-10)13-9-14(19)15-11(2)7-8-17-16(15)18-13/h3-9H,1-2H3,(H,17,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.88E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization interacting at the colchicine binding site.


J Med Chem 43: 167-76 (2000)


Article DOI: 10.1021/jm990333a
BindingDB Entry DOI: 10.7270/Q2CV4JZB
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50059097
PNG
(5-Methyl-2-p-tolyl-1H-[1,8]naphthyridin-4-one | CH...)
Show SMILES Cc1ccc(cc1)-c1cc(O)c2c(C)ccnc2n1
Show InChI InChI=1S/C16H14N2O/c1-10-3-5-12(6-4-10)13-9-14(19)15-11(2)7-8-17-16(15)18-13/h3-9H,1-2H3,(H,17,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization


J Med Chem 40: 2266-75 (1997)


Article DOI: 10.1021/jm960858s
BindingDB Entry DOI: 10.7270/Q26M35ZF
More data for this
Ligand-Target Pair