BDBM50059947 CHEMBL104495::Phosphoric acid mono-{3-hydroxy-5-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-tetrahydro-furan-2-ylmethyl} ester

SMILES Cc1cn(CCC2CC(O)C(COP(O)(O)=O)O2)c(=O)[nH]c1=O

InChI Key InChIKey=NCTOIMQJTKGFPX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50059947   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50059947BDBM50059947(Phosphoric acid mono-{3-hydroxy-5-[2-(5-methyl-2,4...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 uM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50059947BDBM50059947(Phosphoric acid mono-{3-hydroxy-5-[2-(5-methyl-2,4...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii was evaluated using 90 uM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50059947BDBM50059947(Phosphoric acid mono-{3-hydroxy-5-[2-(5-methyl-2,4...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liver was evaluated using 90 uM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed