BDBM50059949 5-(4-Benzylamino-3-nitro-phenyl)-6-ethyl-pyrimidine-2,4-diamine::CHEMBL81294

SMILES CCc1nc(N)nc(N)c1-c1ccc(NCc2ccccc2)c(c1)[N+]([O-])=O

InChI Key InChIKey=AKHJHGFAKBSNDF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50059949   

TargetDihydrofolate reductase(Pneumocystis carinii)
University

Curated by ChEMBL
LigandPNGBDBM50059949(5-(4-Benzylamino-3-nitro-phenyl)-6-ethyl-pyrimidin...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii was evaluated using 90 microM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University

Curated by ChEMBL
LigandPNGBDBM50059949(5-(4-Benzylamino-3-nitro-phenyl)-6-ethyl-pyrimidin...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 microM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50059949(5-(4-Benzylamino-3-nitro-phenyl)-6-ethyl-pyrimidin...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liver was evaluated using 90 microM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed