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BDBM50061494 1-[(2R,3R)-6-Fluoro-3-(thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole::CHEMBL334781

SMILES: Fc1ccc2[C@@H](OCc3ccsc3)[C@@H](Cn3ccnc3)Sc2c1

InChI Key: InChIKey=RHGKIGYCKIEYHG-IAGOWNOFSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50061494   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50061494
PNG
(1-[(2R,3R)-6-Fluoro-3-(thiophen-3-ylmethoxy)-2,3-d...)
Show SMILES Fc1ccc2[C@@H](OCc3ccsc3)[C@@H](Cn3ccnc3)Sc2c1
Show InChI InChI=1S/C17H15FN2OS2/c18-13-1-2-14-15(7-13)23-16(8-20-5-4-19-11-20)17(14)21-9-12-3-6-22-10-12/h1-7,10-11,16-17H,8-9H2/t16-,17-/m1/s1
PDB

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.36E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human farnesyltransferase


J Med Chem 40: 4103-12 (1998)


Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0
More data for this
Ligand-Target Pair