BDBM50061881 3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmethyl-8-aza-bicyclo[3.2.1]octane::CHEMBL440272

SMILES Fc1ccc(cc1)C(OC1CC2CCC(C1)N2CC1CC1)c1ccc(F)cc1

InChI Key InChIKey=PMCPPYXVCCGLLE-UHFFFAOYSA-N

Data  9 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50061881   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061881(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmet...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]WIN35428 from Sprague-Dawley rat brain DAT after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061881(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmet...)
Affinity DataKi:  32.4nMAssay Description:Displacement of [3H]-WIN- 35, 428 from the dopamine transporter in rat caudate putamen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061881(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmet...)
Affinity DataKi:  32.4nMAssay Description:Displacement of [3H]WIN-35428 from the dopamine transporter in rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061881(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmet...)
Affinity DataKi:  136nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M1 sites of ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061881(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmet...)
Affinity DataKi:  180nMAssay Description:In vitro inhibition of dopamine uptake in rat tissue, was determined using [3H]-DAU as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061881(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmet...)
Affinity DataKi:  257nMAssay Description:Compound is tested for displacement of [3H]pirenzepine at Metabotropic glutamate receptor 1 in Rat brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061881(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmet...)
Affinity DataKi:  1.19E+3nMAssay Description:Compound is evaluated for binding to Serotonin transporter using [3H]-Citalopram as radioligand in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061881(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmet...)
Affinity DataKi:  1.42E+3nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat brain SERT after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061881(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmet...)
Affinity DataKi:  4.79E+3nMAssay Description:Compound was evaluated for binding to Norepinephrine Transporter (NET) using [3H]-desmethylimipramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061881(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-cyclopropylmet...)
Affinity DataIC50:  3.96E+3nMAssay Description:Displacement of [3H]Dofetilide from human ERG expressed in HEK cells after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed