BDBM50061977 17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210,17.119,23.011,16.026,31]octatriaconta-1(31),4,6,10(35),11,13,15,17(34),19,21,23(38),25,27,29,32,36-hexadecaene::17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210,17.119,23.011,16.026,31]octatriaconta-1(32),4,6,10(35),11(16),12,14,17(34),19,21,23(38),25(33),26(31),27,29,36-hexadecaene::CHEMBL117908::CHEMBL45193::UCL-1684

SMILES: C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21

InChI Key: InChIKey=RTVXWSMGAUBIJI-UHFFFAOYSA-N

Data: 1 KI  3 IC50  1 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50061977   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Small conductance calcium-activated potassium channel protein 3 (Rattus norvegicus)	BDBM50061977 (17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...) Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NeuroSearch A/S Curated by ChEMBL					Assay Description Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells				J Med Chem 51: 7625-34 (2009) Article DOI: 10.1021/jm800809f BindingDB Entry DOI: 10.7270/Q28S4QT0
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50061977 (17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...) Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50061977 (17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...) Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1 (KCa2.1) (Homo sapiens (Human))	BDBM50061977 (17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...) Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of hSK1 calcium activated potassium channel (SKCa channel)				J Med Chem 44: 1627-53 (2001) Article DOI: 10.1021/jm000484+ BindingDB Entry DOI: 10.7270/Q218376D
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (Rattus norvegicus)	BDBM50061977 (17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...) Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a
NeuroSearch A/S Curated by ChEMBL					Assay Description Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique				J Med Chem 51: 7625-34 (2009) Article DOI: 10.1021/jm800809f BindingDB Entry DOI: 10.7270/Q28S4QT0
					More data for this Ligand-Target Pair