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BDBM50061977 17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210,17.119,23.011,16.026,31]octatriaconta-1(31),4,6,10(35),11,13,15,17(34),19,21,23(38),25,27,29,32,36-hexadecaene::17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210,17.119,23.011,16.026,31]octatriaconta-1(32),4,6,10(35),11(16),12,14,17(34),19,21,23(38),25(33),26(31),27,29,36-hexadecaene::CHEMBL117908::CHEMBL45193::UCL-1684

SMILES: C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21

InChI Key: InChIKey=RTVXWSMGAUBIJI-UHFFFAOYSA-N

Data: 1 KI  3 IC50  1 Kd

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50061977   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50061977
PNG
(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21
Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2
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1.80n/an/an/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells


J Med Chem 51: 7625-34 (2009)


Article DOI: 10.1021/jm800809f
BindingDB Entry DOI: 10.7270/Q28S4QT0
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus-RAT-Rattus norvegicus (Rat))
BDBM50061977
PNG
(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21
Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2
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n/an/a 3n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...


J Med Chem 43: 420-31 (2000)


Article DOI: 10.1021/jm9902537
BindingDB Entry DOI: 10.7270/Q21V5HQ2
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel


(Rattus norvegicus-RAT-Rattus norvegicus (Rat))
BDBM50061977
PNG
(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21
Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2
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n/an/a 3n/an/an/an/an/an/a



Aristotelian University of Thessaloniki

Curated by ChEMBL


Assay Description
Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity


Bioorg Med Chem Lett 14: 4231-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.011
BindingDB Entry DOI: 10.7270/Q2FF3W4T
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1 (KCa2.1)


(Homo sapiens (Human))
BDBM50061977
PNG
(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21
Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2
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n/an/a 3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of hSK1 calcium activated potassium channel (SKCa channel)


J Med Chem 44: 1627-53 (2001)


Article DOI: 10.1021/jm000484+
BindingDB Entry DOI: 10.7270/Q218376D
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Rattus norvegicus)
BDBM50061977
PNG
(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21
Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2
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n/an/an/a 2.70n/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique


J Med Chem 51: 7625-34 (2009)


Article DOI: 10.1021/jm800809f
BindingDB Entry DOI: 10.7270/Q28S4QT0
More data for this
Ligand-Target Pair