BDBM50063129 (R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid::CHEMBL297792

SMILES Cc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O

InChI Key InChIKey=YWCLDDLVLSQGSZ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50063129   

Target72 kDa type IV collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity against Matrix metalloprotease-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 9.60nMAssay Description:Inhibitory activity against Matrix metalloprotease-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloprotease-2 MMP2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against endothelin converting enzyme (ECE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed