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BDBM50063293 CHEMBL165689::Pyrimidin-2-yl-{4-[2-(2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-yl)-ethyl]-cyclohexyl}-amine

SMILES: C(CN1CCN(CC1)c1cnccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1

InChI Key: InChIKey=JEEXKVNFXCLLCQ-IYARVYRRSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50063293   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063293
PNG
(CHEMBL165689 | Pyrimidin-2-yl-{4-[2-(2,3,5,6-tetra...)
Show SMILES C(CN1CCN(CC1)c1cnccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C20H29N7/c1-7-23-20(24-8-1)25-18-4-2-17(3-5-18)6-11-26-12-14-27(15-13-26)19-16-21-9-10-22-19/h1,7-10,16-18H,2-6,11-15H2,(H,23,24,25)/t17-,18-
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PC sid
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Article
PubMed
29n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063293
PNG
(CHEMBL165689 | Pyrimidin-2-yl-{4-[2-(2,3,5,6-tetra...)
Show SMILES C(CN1CCN(CC1)c1cnccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C20H29N7/c1-7-23-20(24-8-1)25-18-4-2-17(3-5-18)6-11-26-12-14-27(15-13-26)19-16-21-9-10-22-19/h1,7-10,16-18H,2-6,11-15H2,(H,23,24,25)/t17-,18-
PDB

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Article
PubMed
180n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50063293
PNG
(CHEMBL165689 | Pyrimidin-2-yl-{4-[2-(2,3,5,6-tetra...)
Show SMILES C(CN1CCN(CC1)c1cnccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C20H29N7/c1-7-23-20(24-8-1)25-18-4-2-17(3-5-18)6-11-26-12-14-27(15-13-26)19-16-21-9-10-22-19/h1,7-10,16-18H,2-6,11-15H2,(H,23,24,25)/t17-,18-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
210n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair