BDBM50063703 2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one::CHEMBL10378

SMILES Ic1ccccc1-c1nc2ccccc2c(=O)o1

InChI Key InChIKey=VEBIXPCJYGGBAF-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50063703   

TargetKallikrein-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  9.89E+3nMAssay Description:Compound was evaluated for inhibitory activity against Kallikrein.More data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.67E+4nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.67E+4nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.53E+4nMAssay Description:Concentration of compound required to inhibit 50% trypsin derived from bovine pancreasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  5.00E+4nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  510nMAssay Description:Compound was evaluated for inhibitory activity against Thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlasminogen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  6.68E+3nMAssay Description:Compound was evaluated for inhibitory activity against plasmin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1s subcomponent(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.25E+3nMAssay Description:Compound was evaluated for inhibitory activity against C1s serine protease .More data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.53E+4nMAssay Description:Compound was evaluated for inhibitory activity against Trypsin.More data for this Ligand-Target Pair
In DepthDetails Article