BDBM50063713 2-Methylamino-benzo[d][1,3]oxazin-4-one::CHEMBL10625

SMILES CNc1nc2ccccc2c(=O)o1

InChI Key InChIKey=DHZSTPSBUNTJIL-UHFFFAOYSA-N

Data  2 KI  1 IC50  2 Koff  1 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50063713   

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50063713(2-Methylamino-benzo[d][1,3]oxazin-4-one | CHEMBL10...)
Affinity DataKi:  6.31E+3nM Kon:  0.0389M-1s-1 Koff:  5.62E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50063713(2-Methylamino-benzo[d][1,3]oxazin-4-one | CHEMBL10...)
Affinity DataKi:  6.90E+3nMAssay Description:Binding affinity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2010
Entry Details Article
PubMed
TargetComplement C1r subcomponent(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063713(2-Methylamino-benzo[d][1,3]oxazin-4-one | CHEMBL10...)
Affinity DataIC50: 6.25E+4nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using Cbz-Gly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50063713(2-Methylamino-benzo[d][1,3]oxazin-4-one | CHEMBL10...)
Affinity DataKon:  0.0380M-1s-1Assay Description:Binding affinity against human leukocyte elastase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2010
Entry Details Article
PubMed