BDBM50063864 CHEMBL3403619::US10676467, Compound TZ 50 13

SMILES OC(=O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(c3)C(F)(F)F)cc21

InChI Key InChIKey=ISBCPWVJRHMKFI-UHFFFAOYSA-N

Data  3 IC50  10 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50063864   

TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at human S1P1 receptor assessed as change in cAMP level by homogeneous time resolved fluorescence cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at human S1P1 receptor assessed as change in cAMP level by homogeneous time resolved fluorescence cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Mus musculus (Mouse))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at mouse S1P1 receptor assessed as change in cAMP level by homogeneous time resolved fluorescence cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Rattus norvegicus)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at rat S1P1 receptor assessed as change in cAMP level by homogeneous time resolved fluorescence cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Canis lupus familiaris)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at dog S1P1 receptor assessed as change in cAMP level by homogeneous time resolved fluorescence cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human S1P1 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataIC50: >1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human S1P3 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  5.80nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataIC50:  8.34nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataIC50: >1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human S1P2 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed