BDBM50064109 CGS-31447::CHEMBL285619::{1-[(S)-2-Biphenyl-4-yl-1-(2H-tetrazol-5-yl)-ethylamino]-3-naphthalen-1-yl-propyl}-phosphonic acid::{1-[2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-3-naphthalen-1-yl-propyl}-phosphonic acid::{1-[2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-3-naphthalen-1-yl-propyl}-phosphonic acid(CGS-31,447)

SMILES OP(O)(=O)C(CCc1cccc2ccccc12)N[C@@H](Cc1ccc(cc1)-c1ccccc1)c1nnn[nH]1

InChI Key InChIKey=HIILOVHYWAEGDS-QBHOUYDASA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50064109   

TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064109(CGS-31447 | CHEMBL285619 | {1-[(S)-2-Biphenyl-4-yl...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064109(CGS-31447 | CHEMBL285619 | {1-[(S)-2-Biphenyl-4-yl...)
Affinity DataIC50:  17nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064109(CGS-31447 | CHEMBL285619 | {1-[(S)-2-Biphenyl-4-yl...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064109(CGS-31447 | CHEMBL285619 | {1-[(S)-2-Biphenyl-4-yl...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed