BDBM50065312 (Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-one::4-Methyl-3-(4-morpholin-4-yl-benzylidene)-1,3-dihydro-indol-2-one::4-Methyl-3-[1-(4-morpholin-4-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL90277

SMILES Cc1cccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c12

InChI Key InChIKey=KBPBXFBACWNRGQ-LGMDPLHJSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50065312   

TargetVascular endothelial growth factor receptor 2(Mus musculus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50065312((Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-...)
Affinity DataIC50:  2.09E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065312((Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065312((Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50065312((Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065312((Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065312((Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-...)
Affinity DataIC50:  4.99E+4nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065312((Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-...)
Affinity DataIC50:  6.66E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed