BDBM50065457 EMD-1214063::MSC-2156119::MSC-2156119J::Tepotinib::US9403799, A14
InChI string: InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
SMILES: CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
InChI Key: InChIKey=AHYMHWXQRWRBKT-UHFFFAOYSA-N
Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono Research& Development Curated by ChEMBL | Assay Description Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay | Bioorg Med Chem Lett 25: 1597-602 (2015) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono Research& Development Curated by ChEMBL | Assay Description Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay | Bioorg Med Chem Lett 25: 1597-602 (2015) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of c-Met (unknown origin) | Eur J Med Chem 108: 495-504 (2016) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK PATENT GMBH US Patent | Assay Description The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ... | US Patent US9403799 (2016) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK PATENT GMBH US Patent | Assay Description The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ... | US Patent US9403799 (2016) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK PATENT GMBH US Patent | Assay Description The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ... | US Patent US9403799 (2016) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK PATENT GMBH US Patent | Assay Description The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ... | US Patent US9403799 (2016) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK PATENT GMBH US Patent | Assay Description The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ... | US Patent US9403799 (2016) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK PATENT GMBH US Patent | Assay Description The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ... | US Patent US9403799 (2016) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK PATENT GMBH US Patent | Assay Description The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ... | US Patent US9403799 (2016) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50065457![]() (EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK PATENT GMBH US Patent | Assay Description The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ... | US Patent US9403799 (2016) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |