BDBM50068755 2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one::CHEMBL125244

SMILES Cc1cccc2c1nc([nH]c2=O)-c1ccc(O)cc1

InChI Key InChIKey=NIPIEXNSQBQPML-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50068755   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068755(2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human tankyrase2 after 2 hrs by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068755(2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one ...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human tankyrase1 after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Mouse)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068755(2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one ...)
Affinity DataIC50: 220nMAssay Description:Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068755(2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one ...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 hr by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068755(2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant IMPDH2 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed