BDBM50069174 Boronate Ester analogue::CHEMBL317682::N-[(5-Amino-1-dihydroxyboranyl-pentylcarbamoyl)-methyl]-N-methyl-3-phenyl-propionamide

SMILES CN(CC(=O)N[C@@H](CCCCN)B(O)O)C(=O)CCc1ccccc1

InChI Key InChIKey=RIUCWNRPWWTWOU-HNNXBMFYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50069174   

TargetProthrombin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069174(Boronate Ester analogue | CHEMBL317682 | N-[(5-Ami...)
Affinity DataKi:  1.70nMAssay Description:Inhibition against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069174(Boronate Ester analogue | CHEMBL317682 | N-[(5-Ami...)
Affinity DataKi:  1.70nMAssay Description:In vitro for inhibition of thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069174(Boronate Ester analogue | CHEMBL317682 | N-[(5-Ami...)
Affinity DataKi:  2.80nMAssay Description:Compound was tested in vitro for inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50069174(Boronate Ester analogue | CHEMBL317682 | N-[(5-Ami...)
Affinity DataKi:  150nMAssay Description:Concentration necessary to double time for clot formation induced by bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlasminogen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069174(Boronate Ester analogue | CHEMBL317682 | N-[(5-Ami...)
Affinity DataKi:  250nMAssay Description:In vitro for inhibition of plasminMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue-type plasminogen activator(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069174(Boronate Ester analogue | CHEMBL317682 | N-[(5-Ami...)
Affinity DataKi:  3.80E+3nMAssay Description:Compound was tested in vitro for inhibition of tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails Article