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BDBM50070328 CHEBI:8862::RILMENIDINE::Rilmenidine

SMILES: C1CC1C(NC1=NCCO1)C1CC1

InChI Key: InChIKey=CQXADFVORZEARL-UHFFFAOYSA-N

Data: 10 KI  4 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50070328   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Imidazoline I1


(RAT)
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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83n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


J Med Chem 58: 878-87 (2015)


Article DOI: 10.1021/jm501456p
BindingDB Entry DOI: 10.7270/Q2R21333
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(Homo sapiens (Human))
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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180n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2 adrenoceptor expressed in CHO cell membranes after 60 mins


J Med Chem 58: 878-87 (2015)


Article DOI: 10.1021/jm501456p
BindingDB Entry DOI: 10.7270/Q2R21333
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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300n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting method


Bioorg Med Chem 24: 3174-83 (2016)


Article DOI: 10.1016/j.bmc.2016.05.043
BindingDB Entry DOI: 10.7270/Q2NZ89J3
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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n/an/an/an/a 178n/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assay


Bioorg Med Chem 24: 3174-83 (2016)


Article DOI: 10.1016/j.bmc.2016.05.043
BindingDB Entry DOI: 10.7270/Q2NZ89J3
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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13n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting method


Bioorg Med Chem 24: 3174-83 (2016)


Article DOI: 10.1016/j.bmc.2016.05.043
BindingDB Entry DOI: 10.7270/Q2NZ89J3
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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n/an/an/an/a 275n/an/an/an/a


TBA

Assay Description
Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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n/an/an/an/a 191n/an/an/an/a


TBA

Assay Description
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens)
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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n/an/an/an/a 724n/an/an/an/a


TBA

Assay Description
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens)
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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71n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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6.03E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards human Alpha-1C adrenergic receptor by the displacement of [3H]prazosin


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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8.91E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards human Alpha-1A adrenergic receptor by the displacement of [3H]prazosin


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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182n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine


Citation and Details
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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4.68E+13n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards human Alpha-1B adrenergic receptor by the displacement of [3H]prazosin


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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288n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscine


Citation and Details
More data for this
Ligand-Target Pair