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BDBM50070734 CHEMBL2372705::CHEMBL263934::Nazumamide A (NAZA) analogue

SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)c1cc(O)ccc1O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC)C(O)=O

InChI Key: InChIKey=XRKRQRZFRIRGEE-GJLLLRFJSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50070734   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50070734
PNG
(CHEMBL2372705 | CHEMBL263934 | Nazumamide A (NAZA)...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)c1cc(O)ccc1O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC)C(O)=O
Show InChI InChI=1S/C28H44N6O9/c1-4-15(3)23(27(41)33-20(10-12-22(30)37)25(39)31-18(5-2)28(42)43)34-26(40)19(8-6-7-13-29)32-24(38)17-14-16(35)9-11-21(17)36/h9,11,14-15,18-20,23,35-36H,4-8,10,12-13,29H2,1-3H3,(H2,30,37)(H,31,39)(H,32,38)(H,33,41)(H,34,40)(H,42,43)/t15-,18-,19-,20-,23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.20E+4n/an/an/an/a8.3n/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Anti-thrombin activity by competitive enzyme assay using the fluorogenic substrate Tos-Gly-Pro-Arg-AMC at pH 8.3.


Bioorg Med Chem Lett 8: 1669-72 (1999)


Article DOI: 10.1016/s0960-894x(98)00281-9
BindingDB Entry DOI: 10.7270/Q2G73CV8
More data for this
Ligand-Target Pair