BDBM50070788 CHEMBL48029::N-(4-(benzyloxy)phenethyl)pyridin-4-amine::[2-(4-Benzyloxy-phenyl)-ethyl]-pyridin-4-yl-amine

SMILES C(Cc1ccc(OCc2ccccc2)cc1)Nc1ccncc1

InChI Key InChIKey=WPBRSJXCRWSAHJ-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50070788   

TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070788(CHEMBL48029 | N-(4-(benzyloxy)phenethyl)pyridin-4-...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070788(CHEMBL48029 | N-(4-(benzyloxy)phenethyl)pyridin-4-...)
Affinity DataKi:  7.90E+3nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070788(CHEMBL48029 | N-(4-(benzyloxy)phenethyl)pyridin-4-...)
Affinity DataKi:  5.68E+5nMAssay Description:Compound was evaluated for its inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070788(CHEMBL48029 | N-(4-(benzyloxy)phenethyl)pyridin-4-...)
Affinity DataIC50:  102nMAssay Description:Antagonist activity at human NR2B expressed in Ltk- cells by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070788(CHEMBL48029 | N-(4-(benzyloxy)phenethyl)pyridin-4-...)
Affinity DataIC50:  130nMAssay Description:Displacement of [35S]MK499 from hERG potassium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070788(CHEMBL48029 | N-(4-(benzyloxy)phenethyl)pyridin-4-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Activity at human NR2A expressed in Ltk- cells by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed