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BDBM50071154 (2R,4R)-4-Amino-1-(3-phenyl-propyl)-pyrrolidine-2,4-dicarboxylic acid::CHEMBL406215

SMILES: N[C@@]1(C[C@@H](N(CCCc2ccccc2)C1)C(O)=O)C(O)=O

InChI Key: InChIKey=DDFIGBGCWDWQQR-IUODEOHRSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50071154   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50071154
PNG
((2R,4R)-4-Amino-1-(3-phenyl-propyl)-pyrrolidine-2,...)
Show SMILES N[C@@]1(C[C@@H](N(CCCc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H20N2O4/c16-15(14(20)21)9-12(13(18)19)17(10-15)8-4-7-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10,16H2,(H,18,19)(H,20,21)/t12-,15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50071154
PNG
((2R,4R)-4-Amino-1-(3-phenyl-propyl)-pyrrolidine-2,...)
Show SMILES N[C@@]1(C[C@@H](N(CCCc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H20N2O4/c16-15(14(20)21)9-12(13(18)19)17(10-15)8-4-7-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10,16H2,(H,18,19)(H,20,21)/t12-,15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50071154
PNG
((2R,4R)-4-Amino-1-(3-phenyl-propyl)-pyrrolidine-2,...)
Show SMILES N[C@@]1(C[C@@H](N(CCCc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H20N2O4/c16-15(14(20)21)9-12(13(18)19)17(10-15)8-4-7-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10,16H2,(H,18,19)(H,20,21)/t12-,15-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 5 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair