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BDBM50071158 (2R,4R)-4-Amino-1-biphenyl-4-ylmethyl-pyrrolidine-2,4-dicarboxylic acid::CHEMBL304034

SMILES: N[C@@]1(C[C@@H](N(Cc2ccc(cc2)-c2ccccc2)C1)C(O)=O)C(O)=O

InChI Key: InChIKey=LBELXPGEJHKDMP-VQIMIIECSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50071158   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50071158
PNG
((2R,4R)-4-Amino-1-biphenyl-4-ylmethyl-pyrrolidine-...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccc(cc2)-c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H20N2O4/c20-19(18(24)25)10-16(17(22)23)21(12-19)11-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16H,10-12,20H2,(H,22,23)(H,24,25)/t16-,19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 5 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50071158
PNG
((2R,4R)-4-Amino-1-biphenyl-4-ylmethyl-pyrrolidine-...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccc(cc2)-c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H20N2O4/c20-19(18(24)25)10-16(17(22)23)21(12-19)11-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16H,10-12,20H2,(H,22,23)(H,24,25)/t16-,19-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50071158
PNG
((2R,4R)-4-Amino-1-biphenyl-4-ylmethyl-pyrrolidine-...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccc(cc2)-c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H20N2O4/c20-19(18(24)25)10-16(17(22)23)21(12-19)11-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16H,10-12,20H2,(H,22,23)(H,24,25)/t16-,19-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50071158
PNG
((2R,4R)-4-Amino-1-biphenyl-4-ylmethyl-pyrrolidine-...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccc(cc2)-c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H20N2O4/c20-19(18(24)25)10-16(17(22)23)21(12-19)11-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16H,10-12,20H2,(H,22,23)(H,24,25)/t16-,19-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair