BDBM50072074 CHEMBL3407847
SMILES CNc1ncc2cc(ccc2n1)-c1c(C)ccc(C(=O)Nc2ccc(OC)c(c2)C(F)(F)F)c1N
InChI Key InChIKey=NYVUSSXLPQHLMH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50072074
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: 640nMAssay Description:Inhibition of GCN2 in amino acid starved human HT1080 cells assessed as inhibition of CHoP mRNA expression preincubated for 1 hr followed by 2 hrs in...More data for this Ligand-Target Pair
3D Structure (crystal)TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human N-terminal His-tagged PERK expressed in Escherichia coli using AviTag C-terminal, N-terminal His-tagged eIF2alpha (3 to 315) as s...More data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of human C-terminal His-tagged GCN2 expressed in Escherichia coli using AviTag C-terminal, N-terminal His-tagged eIF2alpha (3 to 315) as s...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of IRE-1 (unknown origin)More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKR (unknown origin)More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PERK in human HT1080 cells assessed as inhibition of thapsigargin-induced CHoP mRNA expression preincubated for 1 hr followed by thapsi...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant BRAF V600E kinase domain mutant (unknown origin)More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of doxycycline-inducible T-REx-PERK-FLAG (unknown origin) autophosphorylation tranfected in human HT1080 cells after 1 hr by sandwich ELIS...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) transfected in human A375 cells assessed as inhibition of ERK phosphorylation by Western blot analys...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataEC50: 310nMAssay Description:Inhibition of PERK-mediated protein synthesis in human U2OS cells harboring thapsigargin-induced ER stress assessed as incorporation of L-azidohomoal...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HRI (unknown origin)More data for this Ligand-Target Pair