BDBM50072147 (2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile::1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene::1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene monoethanolate::2,3-Bis-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-succinonitrile::2,3-Bis-[amino-(2-amino-phenylsulfanyl)-methylene]-succinonitrile::2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile::2-[1-Amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-3-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(E)-ylidene]-succinonitrile::2-[Amino-(2-amino-phenylsulfanyl)-methylene]-3-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-succinonitrile::CHEMBL100473::CHEMBL95758::U-0126

SMILES Nc1ccccc1SC(=N)C(C#N)C(C#N)C(=N)Sc1ccccc1N

InChI Key InChIKey=ZCHZSBUNJOCWCW-UHFFFAOYSA-N

Data  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50072147   

TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  300nMAssay Description:AP-1 suppression activity using one month old DMSO stockMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  58nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  200nMAssay Description:AP-1 suppression activity using freshly prepared DMSO stockMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of the dual specificity kinase MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  2.48E+4nMAssay Description:AP-1 suppression activity using six months old DMSO stockMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  70nMAssay Description:Inhibition of the dual specificity kinase MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  300nMAssay Description:AP-1 suppression activity using one week old DMSO stockMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  500nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  60nMAssay Description:Inhibition of the dual specificity kinase MEK-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  500nMAssay Description:AP-1 suppression activity using two months old DMSO stockMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  70nMAssay Description:Inhibitory potency against mitogen activated protein kinase kinase kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  58nMAssay Description:Inhibition of MEK2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  72nMAssay Description:Inhibition of MEK1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of human PKBalpha expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of His-tagged human SAPK2a/p38 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 1 (MKK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  250nMAssay Description:Inhibition of N-terminal GST-tagged human BRAF/MEK1/RAF1 Y340D/Y341D double mutant measured after 2 hrs in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of His-tagged human PRAK expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibitory activity against Chymotrypsinogen from Thermus flavusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of p38-regulated activated kinase (Protein kinase PRAK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase(Thermus thermophilus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against malate dehydrogenase (MDH) from Thermus flavusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  290nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  89nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged C-terminal His6-tagged MEK1 expressed in Escherichia coli using myelin basic protei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  72nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  58nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  72nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed