BDBM50072575 (R)-N*1*-[(S)-1-Benzyl-2-(1H-indol-3-yl)-2-oxo-ethyl]-N*4*-hydroxy-2-isobutyl-succinamide::CHEMBL320782

SMILES CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](Cc1ccccc1)C(=O)c1c[nH]c2ccccc12

InChI Key InChIKey=DZVQTAQHEPKNSI-GCJKJVERSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50072575   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072575((R)-N*1*-[(S)-1-Benzyl-2-(1H-indol-3-yl)-2-oxo-eth...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase 2 isolated from human HT-1080 fibrosarcoma cells induced with TNFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072575((R)-N*1*-[(S)-1-Benzyl-2-(1H-indol-3-yl)-2-oxo-eth...)
Affinity DataIC50:  4.30nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072575((R)-N*1*-[(S)-1-Benzyl-2-(1H-indol-3-yl)-2-oxo-eth...)
Affinity DataIC50:  5.60nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072575((R)-N*1*-[(S)-1-Benzyl-2-(1H-indol-3-yl)-2-oxo-eth...)
Affinity DataIC50:  5.10nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase 1 isolated from the culture medium of human skin fibroblasts induced with PMAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed