BDBM50073752 (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-thiophene-2-carbonyl}-amino)-2-methyl-pentanedioic acid::CHEMBL168069::LY-335580

SMILES C[C@](CCC(O)=O)(NC(=O)c1ccc(CCC2CNc3nc(N)nc(N)c3C2)s1)C(O)=O

InChI Key InChIKey=KHOJROSRJZQVSX-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50073752   

TargetDihydrofolate reductase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073752(LY-335580 | (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetr...)
Affinity DataKi:  0.690nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073752(LY-335580 | (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetr...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory activity against recombinant human Thymidylate synthase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50073752(LY-335580 | (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetr...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed