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BDBM50073825 Biphenyl-3-ylmethyl-{2-[(R)-2-(4-hydroxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-4-methyl-pentyl}-phosphinic acid::CHEMBL28039

SMILES: CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C(CC(C)C)CP(O)(=O)Cc1cccc(c1)-c1ccccc1

InChI Key: InChIKey=DCOFBFUFYCNWSS-SVNIRARHSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50073825   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073825
PNG
(Biphenyl-3-ylmethyl-{2-[(R)-2-(4-hydroxy-phenyl)-1...)
Show SMILES CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C(CC(C)C)CP(O)(=O)Cc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C30H37N2O5P/c1-21(2)16-26(29(34)32-28(30(35)31-3)18-22-12-14-27(33)15-13-22)20-38(36,37)19-23-8-7-11-25(17-23)24-9-5-4-6-10-24/h4-15,17,21,26,28,33H,16,18-20H2,1-3H3,(H,31,35)(H,32,34)(H,36,37)/t26?,28-/m1/s1
PDB
MMDB

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Similars

Article
PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair