BDBM50074735 6-(3-(trifluoromethoxy)benzyl)-5,6,7,8-tetrahydroquinazoline-2,4-diamine::6-(3-Trifluoromethoxy-benzyl)-5,6,7,8-tetrahydro-quinazoline-2,4-diamine::CHEMBL266024

SMILES Nc1nc(N)c2CC(Cc3cccc(OC(F)(F)F)c3)CCc2n1

InChI Key InChIKey=GMRSQGMZHOCITF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50074735   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50074735(6-(3-Trifluoromethoxy-benzyl)-5,6,7,8-tetrahydro-q...)
Affinity DataIC50: 14nMAssay Description:The ability to inhibit Toxoplasma gondii Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50074735(6-(3-Trifluoromethoxy-benzyl)-5,6,7,8-tetrahydro-q...)
Affinity DataIC50: 79nMAssay Description:The ability to inhibit rat liver Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50074735(6-(3-Trifluoromethoxy-benzyl)-5,6,7,8-tetrahydro-q...)
Affinity DataIC50: 100nMAssay Description:The ability to inhibit Pneumocystis carinii Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed