BDBM50074740 3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1-methyl-1H-quinolin-4-one::CHEMBL7819

SMILES COc1cc(O)c2c(c1)n(C)cc(-c1cccc(Cl)c1)c2=O

InChI Key InChIKey=VUACFNCXZKTIEY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50074740   

TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074740(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1-methyl-1...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074740(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1-methyl-1...)
Affinity DataIC50:  170nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074740(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1-methyl-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of v-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Novartis

Curated by ChEMBL
LigandPNGBDBM50074740(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1-methyl-1...)
Affinity DataIC50:  2.83E+3nMAssay Description:Inhibition of EGF-dependent mouse keratinocyte MK cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074740(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1-methyl-1...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Epidermal growth factor receptor-dependent phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074740(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1-methyl-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p60 c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Novartis

Curated by ChEMBL
LigandPNGBDBM50074740(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1-methyl-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Platelet-derived growth factor receptor-dependent phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed