BDBM50074884 2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-pyridin-2-yl]-2H-phthalazin-1-one::CHEMBL12412

SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ncc4ccccc4c3=O)c2cc1OC

InChI Key InChIKey=XYZVJIGJAYGNHT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50074884   

LigandPNGBDBM50074884(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataIC50: 0.680nMAssay Description:In vitro inhibition of Phosphodiesterase 4 from guinea pig lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50074884(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataIC50: 250nMAssay Description:In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50074884(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Phosphodiesterase 1 of guinea pig cardiac ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50074884(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Phosphodiesterase 5 of guinea pig lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed