BDBM50075473 CHEMBL3415305

SMILES Cl.OCCCNCCCc1ccc(Cl)c(c1)C(=O)NCC12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=LZBBHFRRZLDHLE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50075473   

TargetP2X purinoceptor 7(Mus musculus)
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50075473(CHEMBL3415305)
Affinity DataIC50:  1.18E+4nMAssay Description:Antagonist activity at P2X7 receptor in LPS-primed mouse J774.A1 cells assessed as inhibition of ATP-induced IL-1beta release after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50075473(CHEMBL3415305)
Affinity DataIC50:  0.230nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced EtBr uptake measured after 2 hrs by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50075473(CHEMBL3415305)
Affinity DataIC50:  0.0600nMAssay Description:Antagonist activity at human P2X7 receptor in LPS/IFN-gamma-differentiated human THP-1 cells assessed as suppression of BzATP-stimulated IL-1beta rel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50075473(CHEMBL3415305)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed