BDBM50075753 4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine::CHEMBL157529

SMILES Fc1ccc(cc1)-c1cc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1

InChI Key InChIKey=QSUCCHXYMZTHEG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50075753   

TargetGlucagon receptor(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075753(4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  430nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075753(4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  90nMAssay Description:Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075753(4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  340nMAssay Description:Antagonist activity at human glucagon receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075753(4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  350nMAssay Description:Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075753(4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  7.00E+3nMAssay Description:Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075753(4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  340nMAssay Description:Inhibitory activity against p38-alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed