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BDBM50076744 CHEMBL3416733

SMILES: CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O

InChI Key:

Data: 11 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50076744   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
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n/an/a 11n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ERAP2 expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-arginyl-7-amido-4-methyl coumarin as s...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
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n/an/a 30n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-leucine-7-amido-4-methyl coumarin as su...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
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n/an/a 33n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ERAP1 expressed in baculovirus infected Sf9 cells using L-leucine-7-amido-4-methyl coumarin as substrate after 5 to 1...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
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n/an/a 33n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ERAP1 using L-AMC as substrate measured for 15 to 30 mins by fluorescence analysis


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
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n/an/a 11n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ERAP2 using R-AMC as substrate measured for 15 to 30 mins by microplate fluorescence reader method


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
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n/an/a 33n/an/an/an/an/an/a



National Center for Scientific Research Demokritos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ERAP1 using L-leucine 7-amido-4-methyl coumarin as substrate after 5 to 10 mins by fluorescence microplate reader met...


ACS Med Chem Lett 7: 681-5 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00084
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
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n/an/a 57n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
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n/an/a 48n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of ERAP1 (unknown origin) expressed in Hi5 cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
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n/an/a 80n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of ERAP2 (unknown origin) expressed in Hi5 cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
PDB
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n/an/a 33n/an/an/an/an/an/a



National Center for Scientific Research Demokritos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ERAP1 using L-leucine 7-amido-4-methyl coumarin as substrate after 5 to 10 mins by fluorescence microplate reader met...


ACS Med Chem Lett 7: 681-5 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00084
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
PDB

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n/an/a 50n/an/an/an/an/an/a



National Center for Scientific Research Demokritos

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus infected insect cells using L-arginine-7-amido-4-methylcoumarine as substra...


ACS Med Chem Lett 8: 333-337 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00505
BindingDB Entry DOI: 10.7270/Q26M390J
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)