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BDBM50076784 CHEMBL10091::N*4*-(2-Bromo-4,6-dimethoxy-phenyl)-2-methyl-6-(2-trifluoromethyl-phenyl)-pyrimidine-4,5-diamine

SMILES: COc1cc(Br)c(Nc2nc(C)nc(c2N)-c2ccccc2C(F)(F)F)c(OC)c1

InChI Key: InChIKey=SKWRPKFNOGMRDP-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50076784   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50076784
PNG
(CHEMBL10091 | N*4*-(2-Bromo-4,6-dimethoxy-phenyl)-...)
Show SMILES COc1cc(Br)c(Nc2nc(C)nc(c2N)-c2ccccc2C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C20H18BrF3N4O2/c1-10-26-17(12-6-4-5-7-13(12)20(22,23)24)16(25)19(27-10)28-18-14(21)8-11(29-2)9-15(18)30-3/h4-9H,25H2,1-3H3,(H,26,27,28)
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Article
PubMed
60n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Antagonistic activity for Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 1063-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00133-x
BindingDB Entry DOI: 10.7270/Q21V5D5N
More data for this
Ligand-Target Pair