BDBM50077231 CHEMBL54091::N-[4-(3-Bromo-4-fluoro-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-acrylamide

SMILES Fc1ccc(Nc2ncnc3cnc(NC(=O)C=C)cc23)cc1Br

InChI Key InChIKey=HIONRJFCDLKILS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50077231   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50077231(CHEMBL54091 | N-[4-(3-Bromo-4-fluoro-phenylamino)-...)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50077231(CHEMBL54091 | N-[4-(3-Bromo-4-fluoro-phenylamino)-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of heregulin-stimulated autophosphorylation of ERBB2 receptor kinase in MDA-MB-453 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50077231(CHEMBL54091 | N-[4-(3-Bromo-4-fluoro-phenylamino)-...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor (EGFR) in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed