BDBM50077244 CHEMBL31815::N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide

SMILES Cc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1

InChI Key InChIKey=AWQLTDUXGVCRBV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50077244   

TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077244(N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide | CH...)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077244(N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide | CH...)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077244(N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide | CH...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of heregulin-stimulated autophosphorylation of ERBB2 receptor kinase in MDA-MB-453 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077244(N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide | CH...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077244(N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide | CH...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor in A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50077244(N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide | CH...)
Affinity DataIC50: 22nMAssay Description:Inhibition of autophosphorylation of ERBB2 receptor kinase in MDA-MB 453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed