BDBM50077553 1-{4-[3-(3,5-Dichloro-phenyl)-prop-2-ynylsulfanyl]-[1,2,5]thiadiazol-3-yl}-4-aza-tricyclo[2.2.1.0*2,6*]heptane::CHEMBL60479

SMILES Clc1cc(Cl)cc(c1)C#CCSc1nsnc1C12CN3CC1C2C3

InChI Key InChIKey=XGQNOXOBJWAAST-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50077553   

TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077553(1-{4-[3-(3,5-Dichloro-phenyl)-prop-2-ynylsulfanyl]...)
Affinity DataEC50:  528nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077553(1-{4-[3-(3,5-Dichloro-phenyl)-prop-2-ynylsulfanyl]...)
Affinity DataIC50: 788nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077553(1-{4-[3-(3,5-Dichloro-phenyl)-prop-2-ynylsulfanyl]...)
Affinity DataEC50:  1.81E+3nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed