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BDBM50078238 2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester::CHEMBL439925

SMILES: CCOC(=O)C1=C(C)N=C2SC(=CN2C1c1ccccc1OC)c1c(Cl)cccc1Cl

InChI Key: InChIKey=FBASMBMCSXJNML-UHFFFAOYNA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50078238   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50078238
PNG
(2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-met...)
Show SMILES CCOC(=O)C1=C(C)N=C2SC(=CN2C1c1ccccc1OC)c1c(Cl)cccc1Cl
Show InChI InChI=1/C23H20Cl2N2O3S/c1-4-30-22(28)19-13(2)26-23-27(21(19)14-8-5-6-11-17(14)29-3)12-18(31-23)20-15(24)9-7-10-16(20)25/h5-12,21H,4H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.00E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Inhibition of 1S,3R-ACPD (10 microM) -stimulated GTP gamma 35S binding on rat Metabotropic glutamate receptor 2 transfected in CHO cells


Bioorg Med Chem Lett 9: 1573-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00227-9
BindingDB Entry DOI: 10.7270/Q2XS5TKC
More data for this
Ligand-Target Pair