BDBM50078323 CHEMBL3414709

SMILES [H][C@]12CSC(N)=N[C@]1(CO[C@@H](CC)C2)c1ccc(F)cc1F

InChI Key InChIKey=LLMQRTLFGJQYQQ-ZSGNIPIJSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50078323   

TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078323(CHEMBL3414709)
Affinity DataIC50:  59nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078323(CHEMBL3414709)
Affinity DataIC50:  470nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078323(CHEMBL3414709)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of CatD (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed